JERUSALEM (Reuters) - Teva Pharmaceutical Industries and Active Biotech will discontinue higher doses of their oral drug in development for multiple sclerosis in two trials, citing the occurrence of non-fatal cardiovascular events in eight patients. Both trials of laquinimod will continue with the lower dose of 0.6 mg daily where there were no issues. Israel-based Teva and Sweden's Active Biotech said a monitoring committee had identified an imbalance in the number of cardiovascular events in patient trials using 1.2 mg and 1.5 mg daily doses. "Teva is notifying trial sites to discontinue the higher doses immediately in both trials and will encourage participants to continue follow ups," it said in a statement on Monday. Through a licensing agreement, Teva has global rights to develop and commercialize laquinimod, a small-molecule entity discovered by Active Biotech. (Reporting by Steven Scheer)
The debate might've been even weirder than we thought.
- Buccaneers Wire
See what Rob Gronkowski had to say to Tom Brady following the GOAT's second retirement announcement
Tom Brady is looking back at special times with the people closest to him, which include ex Bridget Moynahan, with whom he shares son Jack
Jessica Simpson Reveals How a 'Massive Movie Star' Tried to Seduce Her: 'I Thought I Would Never Share It!'
The singer and clothing designer writes about a world-famous actor who pursued her (though he wasn't single) in a new piece for Amazon Original Stories.
In a new interview, Meghan Markle opens up about how she and Prince Harry were initially not able to afford their $14 million home in Montecito after stepping..
Mahogany Geter, a model in Tennessee, was born with lymphedema in her left leg, which she says caused it to eventually swell to 100 pounds.
- Patriots Wire
This was Bill Belichick's statement regarding Tom Brady's retirement on Wednesday.
- Broncos Wire
Tom Brady is retiring again, and the Broncos had a perfect response.
Tom Brady announced Wednesday morning that he's ending his NFL career "for good"
Research Highlights: Close review of MRI scans found more intensive high blood pressure treatment (targeted to achieve a systolic pressure less than 120 mm Hg) was more effective than a less-intense treatment goal of 140 mm Hg systolic in achieving a ...
- Yahoo Sports
Jimmy G is headed elsewhere in free agency.
With the United States expected to send a new longer-range weapon to Ukraine, it has answered President Volodymyr Zelenskiy's plea for rockets that can strike deep behind the front lines of the nearly year-long conflict with Russia. Now Russian forces will need to adapt or face potentially catastrophic losses. The new weapon, the Ground Launched Small Diameter Bomb (GLSDB), will allow Ukraine's military to hit targets at twice the distance reachable by the rockets it now fires from the U.S.-supplied High Mobility Artillery Rocket System (HIMARS).
- The Daily Beast
Photo by Win McNamee/Getty ImagesFormer President Donald Trump appears to have lied in sworn court records, opening him up to severe sanctions by a New York judge who has already lost his patience and threatened to punish him before.Trump claimed he wasn’t the president of the Trump Organization during his four years at the White House, despite previously testifying that he was an “inactive president.” And he claimed that he didn’t have a financial stake in a partnership with the real estate com
- Bengals Wire
Joe Burrow and Patrick Mahomes met at midfield after the game.
- Fox News
Hard rock singer Ozzy Osbourne has canceled his 2023 European tour dates due to an old spine injury preventing him from traveling extensively after suffering several other health issues in the past.
- The Weather Network
Extreme weather triggered additional methane release, while the atmosphere lost some of its ability to break down the heat-trapping gas.
- Associated Press
A federal judge in Wisconsin ruled Wednesday that a wrongful death lawsuit filed by the father of a man shot and killed by Kyle Rittenhouse during a protest in 2020 can proceed against Rittenhouse, police officers and others. The father of Anthony Huber, one of two men shot and killed by Rittenhouse, filed the lawsuit in 2021, accusing officers of allowing for a dangerous situation that violated his son's constitutional rights and resulted in his death. Anthony Huber's father, John Huber, also alleged that Rittenhouse, who was 17 at the time of the shootings, conspired with law enforcement to cause harm to protestors.
Tom Brady is celebrating his family, friends and teammates following his retirement announcement by sharing dozens of never-before-seen photos.
- Democrat and Chronicle
There is one issue that has yet to be resolved, though, and it’s a big one. Maybe the biggest of all.
- HuffPost Life
This is what happens when a one-upper comes to the table.