The school in Storrs, Connecticut, became the first program in college football's top flight to spike 2020 play.
"After receiving guidance from state and public health officials and consulting with football student-athletes, we've decided that we will not compete on the gridiron this season," UConn Athletic Director David Benedict said in a statement.
"The safety challenges created by COVID-19 place our football student-athletes at an unacceptable level of risk," he said.
Then hours after UConn's announcement, the NCAA said that it's lowest tier, Division III, will not hold playoffs for all fall sports, including football. Shortly after that, the NCAA announced that Division II would also cancel championships.
The NCAA's move follows weeks of individual Division III schools and conferences preemptively saying theywouldn't play football or any other fall sports in 2020 due to the pandemic.
It's still not clear if the top levels of college football, the Football Bowl Subdivision and Football Championship Subdivision, will have playoffs or take the field at all this fall.
"With the health and safety of the division’s student-athletes, coaches, athletics administrators and communities as its priority, the Division III Presidents Council made the decision Wednesday to cancel the championships due to the COVID-19 pandemic and related administrative and financial challenges," according to the NCAA statement.
Similarly, the NCAA said Division II canceled the fall championships "due to the operational, logistical and financial challenges presented by the COVID-19 pandemic."
The UConn Huskies play in the Football Bowl Subdivision of college football, one of the sport's top tiers.
The school's announcement comes despite the state of Connecticut having driven its rate of positive tests to just 1.24 percent, among the nation's lowest, according to data collected Wednesday morning by Johns Hopkins University.
As the nation continues to struggle with COVID-19, major college football alliances like the Big Ten, Pacific-12 and Southeastern Conferences are dialing back their seasons by cancelling non-conference contests for 2020.
But the Huskies play football as an independent program, thus having to build a schedule without the benefit of built-in conference rivals.
UConn officials are banking on the virus being under control before fall 2021, when the Huskies can play again.
"We engaged and listened to the concerns of our football student-athletes and feel this is the best decision for their health, safety, and well-being," UConn Coach Randy Edsall said in a statement.
"Our team is united in this approach and we will use this time to further player development within the program and gear ourselves to the 2021 season."
With the coronavirus pandemic still raging, football's viability for the fall remains in question for every level of play.
In the second highest level of the college game, the Football Championship Subdivision, the Ivy League, Patriot League, Colonial Athletic Association, Northeast Conference, Southwestern Athletic Conference and Mid-Eastern Athletic Conference have all pulled the plug on fall football, citing the health concerns.
High school sports officials in Minnesota announced on Tuesday that its football season was being shifted to spring 2021. California, New Mexico, Washington, Nevada, Colorado, Illinois, Virginia, Maryland and the District of Columbia have all also opted to move high school football out of the traditional fall window.
The National Junior College Athletic Association announced last month it was shifting football to the spring.
The NFL is, for now, still planning to go forward with its fall season. But supporters of the New York Jets and Giants — both based in New Jersey — and the Las Vegas Raiders have already been told there will be no fans in their home stadiums in 2020.