Quique Setien’s side lead rivals Real Madrid on goal difference heading into the fixture, while Valencia are currently sitting in seventh, 10 points adrift of the runaway leaders.
It will be Setien’s third game in charge of the club and he will be hoping for an improved performance from his team after an indifferent outing against UD Ibiza in the Copa del Rey during week.
Valencia did little to regain momentum in a 1-0 win over Logrones in their round of 32 tie, after being hammered 4-1 by Mallorca last weekend, when captain Daniel Parejo was sent off.
Here is everything you need to know:
When is it?
The match kicks off at 3pm (BST) on Saturday 25 January.
How can I watch it?
The game will be broadcast live on LaLiga TV via Premier Sports with coverage beginning as early as 11am.
Valencia: Los Che will be without Dani Parejo due to suspension, while Cristiano Piccini, Goncalo Guedes and Manu Vallejo are all ruled out with injury. However, striker Rodrigo may be able to return from a knee injury amid links that he could move to the Nou Camp this month, meaning Maxi Gomez may well miss out on a place in the starting eleven.
Barcelona: Jordi Alba, Samuel Umtiti and Arturo Vidal are all likely to return, while Nelson Semedo and Ansu Fati could drop to the bench. Ousmane Dembele and Luis Suarez remain absent, while Neto is also a doubt having sprained his ankle against Ibiza.
Valencia: Domenech; Wass, Paulista, Garay, Gaya; Ferran, Kondogbia, Coquelin, Soler; Gomez, Gameiro
Barcelona: Ter Stegen; Sergi Roberto, Piqué, Umtiti, Jordi Alba; Arthur, Busquets, Frenkie de Jong; Messi, Griezmann, Ansu Fati.
Valencia have a strong recent record against the Spanish champions, famously defeating them in the Copa del Rey final last year to end the club’s trophy drought. However, Barcelona are likely to be re-motivated after a somewhat disappointing performance against Ibiza under Quique Setien. Antoine Griezmann found form in the fixture, scoring twice, while Lionel Messi was rested. Ultimately, the superior quality should shine through.
Valencia 1-3 Barcelona