The Japanese avant-garde artist will be the first woman to design a balloon for the parade's Blue Sky Gallery program, which was launched in 2005.
Over the years, the initiative has invited world-renowned artists to create original designs for Macy's annual Thanksgiving Day Parade, including Jeff Koons, Takashi Murakami and KAWS.
For this year's parade, Kusama will present a sculptural balloon poetically titled "Love Flies up to the Sky," which features the artist's signature polka dots and tentacles.
The floating artwork, which takes the form of an open-mouthed sun, is very reminiscent of the Sun-like figures featured in the Japanese artist's "My Eternal Soul" series.
As ARTnews points out, "Love Flies up to the Sky" was created in collaboration between Kusama's studio and Macy's balloon specialists.
"Her work lends itself to that playful whimsy that we like to see in the sky. What's fantastic about her art, and why I think she's so world-renowned, is that it is so accessible. Everyone can look at her art and appreciate it, understand it, and feel something from it, and that's what we're trying to do," Susan Tercero, the parade's executive producer, told ARTnews.
This 93rd edition of Macy's annual Thanksgiving Day Parade will take place on November 26 from 9am to 12 pm (EST) in New York City.
The parade, which attracts every year an average of 50 million viewers on television, will coincide with Kusama's upcoming exhibition at David Zwirner Gallery opening on November 9.
The exhibit will include the avant-garde artist's signature polka-dot paintings and installations, along with a new Infinity Room.
Some 75,000 people visited Kusama's two-venue exhibition at David Zwirner Gallery in 2017, which also featured two new Infinity Rooms.