The Steelers are -180 on the moneyline in the game, which will be played at Acrisure Stadium in Pittsburgh.
The Jets are +155.
The over/under for the game is set at 41.5 points.
The Jets are coming off a 27-12 loss against the Cincinnati Bengals
The Steelers lost to the Cleveland Browns, 29-17.
These teams did not play each other last season.
The NFL Week 4 game is scheduled to kick off at 10 a.m. MST Sunday and can be seen on CBS.
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This article originally appeared on Arizona Republic: New York Jets vs. Pittsburgh Steelers NFL Week 4 game betting odds